Jean-Christophe BORIES
PhD
Armand BENSUSSAN
PhD
List and affiliations of the 10 members of the Scientific Committee.
Head of Skin research center and of UMR-s-976 unit: Onco-Dermatology, Immunology and Cutaneous stem cells
Pr Bensussan is a member of the American Association of Immunology and of the French Society of Immunology.
He is the co-founder of the biotechnology company Orega Biotech.
Our research work mainly focuses on three themes, which are the oncodermatology, chronic skin inflammation and tissue regeneration. We combine molecular, functional and genetic approaches to identify new targets for the diagnostic and the therapy of pathologies associated with the skin such as melanomas, cutaneous T-cell lymphomas (CTCLs) and psoriasis.
Head of EA 3963 unit: Differentiation of lymphoid cells, Lymphoid disorders and Immuno-Deficiencies
Lymphocytes are hematopoietic cells whose function is critical for the immune response. Their development relies on a complex network of proteins including cell surface receptors, signaling molecules and transcription factors. Our team seeks to identify, among these elements, those who control the physiological differentiation of lymphocytes and the alteration of which leads to immunodeficiencies or haematological malignancies.
Team leader in UMR-1131: Myeloid hemopathies: stem cells, precinical models and translational research
The lab manage several projects that all have in common the integrated analysis of pathways that control differentiation, proliferation, survival, renewal, and stemcellness with the goal of identifying novel strategies for the targeting of cancer progenitor and stem cells.
Head of UMR_E unit: Hemato-Immunology (SRHI)
Pr Carosella is a member of the French Academy of Sciences and of the European Academy of Sciences. He is a recipient of the French National Order of the Legion of Honour.
His work is dedicated to the study of HLA-G molecule and especially its role in maternal-fetal tolerance, organ transplantation and tumor dissemination.
Christine CHOMIENNE
PhD
Edgardo CAROSELLA
MD, PhD
François CLAVEL
PhD
Florence DEMENAIS
MD, PhD
Head of UMR-S-941 unit: Genetics and Ecology of Viruses
Le lab research focuses on the study of HIV evolution under selective pressure by adaptive immunity, innate immunity and intrinsic immunity. In parallel, they study the impact of virus evolution on the physiopathology of HIV infection.
Head of UMR- S-946 unit: Genetic Variability and Human Diseases
The main objectives of the research program are to identify the genetic factors involved in human diseases, to understand their mechanisms and to characterize the other risk factors which may modulate the expression of these genes.
Hugues DE THE
MD, PhD
Hervé DOMBRET
MD, PhD
Head of U 944/UMR 7212 unit: Molecular Pathology and Virology
Pr de Thé is member of the French Academy of Sciences.
His major interest is the pathogenesis and basis for therapy response of a rare malignancy, acute promyelocytic leukemia. This disease is driven by the PML/RARA fusion protein and both retinoic acid and arsenic, two clinically active drugs, target PML/RARA for degradation. The lab provided many insights into APL biology, primarily using experimental therapeutics in various mouse models of the disease.
Head of EA 3518 unit: Clinical Research in Hematology
Pr Dombret is the Director of the Institute of Hematology (IUH) of Saint-Louis.
The team lead translational research on several field including: leukemia, transplantation, myelodysplasia and immunodeficiency.
Anne JANIN
MD, PhD
Antoine TOUBERT
MD, PhD
Head of UMR-S728 unit: Cancer and Transplantation: Pathophysiology and Therapeutic responses
The project's main objective is to explore, from biopsies of patients and in mouse models, the cellular and molecular mechanisms involved in the therapeutic response to aggressive forms of lymphoma and breast cancer, which have the same lines of chemotherapy .
Team leader in UMR-S-940: Hematology-Immunology-Therapeutic targets and CIB (Biomedical Investigattion Center)
INSERM unit "Alloimmunity-Autoimmunity-Transplantation" is specifically devoted to the study of basic mechanisms of allorecognition in solid organ and hematopoietic stem cell transplantation. Autoimmunity (inflammatory bowel diseases) and Tumor immunity in leukemias and melanomas are also in the focus of our scientific objectives, especially with regard to the role of unconventional lymphocyte populations (iNKT, MAIT).